Abstract

Further studies will be carried out on the interesting new B cell lymphoid lines with characteristics of B cell precursors. Membrane Ig studies will be carried out on IgD to see if it has the same tail as IgM to permit it to fit into the membrane.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI010811-20
Application #
3124821
Study Section
Experimental Immunology Study Section (EI)
Project Start
1978-01-01
Project End
1987-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Rockefeller University
Department
Type
Graduate Schools
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Messmer, Davorka; Messmer, Bradley; Chiorazzi, Nicholas (2003) The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells. Int Immunol 15:491-503
Miura, Yasushi; Chu, Charles C; Dines, David M et al. (2003) Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion. Mol Med 9:166-74
Chiorazzi, Nicholas; Ferrarini, Manlio (2003) B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol 21:841-94
Damle, Rajendra N; Ghiotto, Fabio; Valetto, Angelo et al. (2002) B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 99:4087-93
Gurrieri, Carmela; McGuire, Peter; Zan, Hong et al. (2002) Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. J Exp Med 196:629-39
Dono, M; Zupo, S; Massara, R et al. (2001) In vitro stimulation of human tonsillar subepithelial B cells: requirement for interaction with activated T cells. Eur J Immunol 31:752-6
Itoh, K; Patki, V; Furie, R A et al. (2000) Clonal expansion is a characteristic feature of the B-cell repetoire of patients with rheumatoid arthritis. Arthritis Res 2:50-8
Colombo, M; Dono, M; Gazzola, P et al. (2000) Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J Immunol 164:2782-9
Itoh, K; Meffre, E; Albesiano, E et al. (2000) Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes. J Exp Med 192:1151-64
Damle, R N; Wasil, T; Fais, F et al. (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840-7

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