Abstract

This project continues to investigate the cellular mechanisms which control thymus-dependent (T cell) immunity in contact hypersensitivity. Special emphasis is given to examining the properties of immune and suppressor T cells with respect to the nature of their antigen receptors and genetic interactions. We are continuing our studies on the antigen-specific suppressor factor with respect to its biological and physical/chemical properties.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI012993-10A2
Application #
3125338
Study Section
Immunobiology Study Section (IMB)
Project Start
1976-06-01
Project End
1991-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
10
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Moorhead, J W; Clayton, G H; Smith, R L et al. (1999) A replication-incompetent adenovirus vector with the preterminal protein gene deleted efficiently transduces mouse ears. J Virol 73:1046-53
Diiulio, N A; Fairchild, R L; Caulfield, M J (1997) The anti-erythrocyte autoimmune response of NZB mice. Identification of two distinct autoantigens. Immunology 91:246-51
Abe, M; Kondo, T; Xu, H et al. (1996) Interferon-gamma inducible protein (IP-10) expression is mediated by CD8+ T cells and is regulated by CD4+ T cells during the elicitation of contact hypersensitivity. J Invest Dermatol 107:360-6
Barbo, J V; McCormack, J E; Moorhead, J W et al. (1995) Reconstitution of TCR alpha-chain expression in deletion mutants restores dinitrophenyl-specific/class I MHC-restricted suppressor molecule production. J Immunol 154:1551-9
Fairchild, R L; Palmer, E; Moorhead, J W (1993) Production of DNP-specific/class I MHC-restricted suppressor molecules is linked to the expression of T cell receptor alpha- and beta-chain genes. J Immunol 150:67-77
Fairchild, R L; Moorhead, J W (1991) Soluble factors in tolerance and contact sensitivity to DNFB in mice. X. IL-2 is the activation signal mediating release of synthesized suppressor factor. Cell Immunol 133:147-60
Fairchild, R L; Kubo, R T; Moorhead, J W (1990) DNP-specific/class I MHC-restricted suppressor molecules bear determinants of the T cell receptor alpha- and beta-chains. The V beta 8+ chain dictates restriction to either K or D. J Immunol 145:2001-9
Fairchild, R L; Moorhead, J W (1988) Soluble factors in tolerance and contact sensitivity to DNFB in mice. VIII. Regulation of T suppressor cell function by autoreactive T helper cells. Cell Immunol 117:35-44
Fairchild, R L; Kubo, R T; Moorhead, J W (1988) Soluble factors in tolerance and contact sensitivity to 2,4-dinitro-fluorobenzene in mice. IX. A monoclonal T cell suppressor molecule is structurally and serologically related to the alpha/beta T cell receptor. J Immunol 141:3342-8
Fairchild, R L; Moorhead, J W (1987) Soluble factors in tolerance and contact sensitivity to DNFB in mice. VII. Characterization of a monoclonal, efferent-acting suppressor factor with specificity for DNP/H-2Kd. Cell Immunol 105:147-60

Showing the most recent 10 out of 14 publications