Abstract

Peritonitis continues to be a serious clinical problem which is only partially alleviated by antibiotics and appropriate surgical correction. Evidence strongly supports the idea that the prompt clearance of bacteria from the peritoneal cavity is essential to prevent the progression of this disease and that the basic defense mechanisms of the peritoneal cavity in peritonitis need to be defined and augmented. In particular, the aims of this grant are (1) to study the mechanism(s) of the adjuvant action of hemoglobin and other substances on bacterial clearance from the peritoneal cavity of rats, (2) to determine whether certain bacterial species act synergistically in experimental peritonitis, and to determine the mechanism of such interaction, (3) to study possible nonphagocytic mechanisms of bacterial clearance from the peritoneal cavity, (4) to treat experimental peritonitis by increasing the number and/or activity of leukocytes within the peritoneal cavity, (5) to investigate the role of fibrin, fibrinolytic agents and anticoagulants on experimental peritonitis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI014032-07
Application #
3125613
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1978-04-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Wang, Jin; Grishin, Anatoly V; Ford, Henri R (2016) Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol 196:5130-7
Grishin, Anatoly; Bowling, Jordan; Bell, Brandon et al. (2016) Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg 51:13-7
Al Alam, Denise; Danopoulos, Soula; Schall, Kathy et al. (2015) Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol 308:G678-90
McElroy, Steven J; Castle, Shannon L; Bernard, Jessica K et al. (2014) The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol 184:2768-78
Papillon, Stephanie; Castle, Shannon L; Gayer, Christopher P et al. (2013) Necrotizing enterocolitis: contemporary management and outcomes. Adv Pediatr 60:263-79
Ford, Henri R; Hackam, David J (2013) Management of premature infants. Preface. Semin Pediatr Surg 22:67-8
Grishin, Anatoly; Papillon, Stephanie; Bell, Brandon et al. (2013) The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg 22:69-75
Short, Scott S; Wang, Jin; Castle, Shannon L et al. (2013) Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. Lab Invest 93:1265-75
Liu, Quin; Mittal, Rahul; Emami, Claudia N et al. (2012) Human isolates of Cronobacter sakazakii bind efficiently to intestinal epithelial cells in vitro to induce monolayer permeability and apoptosis. J Surg Res 176:437-47
Emami, Claudia N; Mittal, Rahul; Wang, Larry et al. (2012) Role of neutrophils and macrophages in the pathogenesis of necrotizing enterocolitis caused by Cronobacter sakazakii. J Surg Res 172:18-28

Showing the most recent 10 out of 92 publications