Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI014753-16A1
Application #
2060106
Study Section
Special Emphasis Panel (ZRG5-TMP (01))
Project Start
1978-08-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Boston
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02125
Sugumaran, Manickam (2002) Comparative biochemistry of eumelanogenesis and the protective roles of phenoloxidase and melanin in insects. Pigment Cell Res 15:2-9
Sugumaran, M (2001) Control mechanisms of the prophenoloxidase cascade. Adv Exp Med Biol 484:289-98
Chase, M R; Sugumaran, M (2001) Genomic and cDNA sequence of prophenoloxidases from Drosophila melanogaster. Adv Exp Med Biol 484:349-62
Chase, M R; Raina, K; Bruno, J et al. (2000) Purification, characterization and molecular cloning of prophenoloxidases from Sarcophaga bullata. Insect Biochem Mol Biol 30:953-67
Sugumaran, M; Nellaiappan, K; Valivittan, K (2000) A new mechanism for the control of phenoloxidase activity: inhibition and complex formation with quinone isomerase. Arch Biochem Biophys 379:252-60
Sugumaran, M; Nellaiappan, K; Amaratunga, C et al. (2000) Insect melanogenesis. III. Metabolon formation in the melanogenic pathway-regulation of phenoloxidase activityy by endogenous dopachrome isomerase (decarboxylating) from Manduca sexta. Arch Biochem Biophys 378:393-403
Sugumaran, M (2000) Oxidation chemistry of 1,2-dehydro-N-acetyldopamines: direct evidence for the formation of 1,2-dehydro-N-acetyldopamine quinone. Arch Biochem Biophys 378:404-10
Sugumaran, M; Nellaiappan, K (2000) Characterization of a new phenoloxidase inhibitor from the cuticle of Manduca sexta. Biochem Biophys Res Commun 268:379-83
Sugumaran, M; Duggaraju, R; Generozova, F et al. (1999) Insect melanogenesis. II. Inability of Manduca phenoloxidase to act on 5,6-dihydroxyindole-2-carboxylic acid. Pigment Cell Res 12:118-25
Sugumaran, M; Duggaraju, P; Jayachandran, E et al. (1999) Formation of a new quinone methide intermediate during the oxidative transformation of 3,4-dihydroxyphenylacetic acids: implication for eumelanin biosynthesis. Arch Biochem Biophys 371:98-106

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