Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI015035-19
Application #
2060156
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1979-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of South Alabama
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688

  Publications

Housley, Nicole A; Winkler, Herbert H; Audia, Jonathon P (2011) The Rickettsia prowazekii ExoU homologue possesses phospholipase A1 (PLA1), PLA2, and lyso-PLA2 activities and can function in the absence of any eukaryotic cofactors in vitro. J Bacteriol 193:4634-42
Audia, Jonathon P; Winkler, Herbert H (2006) Study of the five Rickettsia prowazekii proteins annotated as ATP/ADP translocases (Tlc): Only Tlc1 transports ATP/ADP, while Tlc4 and Tlc5 transport other ribonucleotides. J Bacteriol 188:6261-8
Audia, Jonathon P; Roberts, Rosemary A W; Winkler, Herbert H (2006) Cysteine-scanning mutagenesis and thiol modification of the Rickettsia prowazekii ATP/ADP translocase: characterization of TMs IV-VII and IX-XII and their accessibility to the aqueous translocation pathway. Biochemistry 45:2648-56
Alexeyev, Mikhail F; Roberts, Rosemary A W; Daugherty, Robin M et al. (2004) Cysteine-scanning mutagenesis and thiol modification of the Rickettsia prowazekii ATP/ADP translocase: evidence that transmembrane regions I and II, but not III, are structural components of the aqueous translocation channel. Biochemistry 43:6995-7002
Daugherty, Robin M; Linka, Nicole; Audia, Jonathon P et al. (2004) The nucleotide transporter of Caedibacter caryophilus exhibits an extended substrate spectrum compared to the analogous ATP/ADP translocase of Rickettsia prowazekii. J Bacteriol 186:3262-5
Linka, Nicole; Hurka, Herbert; Lang, B Franz et al. (2003) Phylogenetic relationships of non-mitochondrial nucleotide transport proteins in bacteria and eukaryotes. Gene 306:27-35
Schwoppe, Christian; Winkler, Herbert H; Neuhaus, H Ekkehard (2003) Connection of transport and sensing by UhpC, the sensor for external glucose-6-phosphate in Escherichia coli. Eur J Biochem 270:1450-7
Winkler, Herbert H; Daugherty, Robin M; Audia, Jonathon P (2003) Cysteine-scanning mutagenesis and thiol modification of the Rickettsia prowazekii ATP/ADP translocase: evidence that TM VIII faces an aqueous channel. Biochemistry 42:12562-9
Alexeyev, Mikhail F; Winkler, Herbert H (2002) Complete replacement of basic amino acid residues with cysteines in Rickettsia prowazekii ATP/ADP translocase. Biochim Biophys Acta 1565:136
Schwoppe, Christian; Winkler, Herbert H; Neuhaus, H Ekkehard (2002) Properties of the glucose-6-phosphate transporter from Chlamydia pneumoniae (HPTcp) and the glucose-6-phosphate sensor from Escherichia coli (UhpC). J Bacteriol 184:2108-15

Showing the most recent 10 out of 52 publications