Abstract

The long-term objective of our research is to understand the molecular mechanism by which immune T lymphocytes recognize antigen through self restriction. It appears that recognition systems for foreign antigens have evolved from self-recognition mechanisms and that highly polymorphic self markers, the histocompatibility antigens are central to this process. For some years we have been studying the structure of human histocompatibility (HLA antigens and a complete amino acid sequence for one antigen has been recently completed. We are now at a point where comparative studies to answer the many questions raised by the functionally important, serologically detected poly-morphism of these molecules can be undertaken. This goal is aided by the availability of monoclonal antibodies which provide more reliable tools for defining these questions. The problems to be investigated have emerged as a consequence of our analysis of anti-HLA-A,B,C monoclonal antibodies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI017892-05
Application #
3127494
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1981-05-01
Project End
1989-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Nemat-Gorgani, Neda; Hilton, Hugo G; Henn, Brenna M et al. (2018) Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2+ HLA-C in Two Indigenous Human Populations in Southern Africa. J Immunol 200:2640-2655
Huhn, Oisín; Chazara, Olympe; Ivarsson, Martin A et al. (2018) High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia. J Immunol 201:2593-2601
Misra, Maneesh K; Augusto, Danillo G; Martin, Gonzalo Montero et al. (2018) Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop. Hum Immunol 79:825-833
Hilton, Hugo G; Parham, Peter (2017) Missing or altered self: human NK cell receptors that recognize HLA-C. Immunogenetics 69:567-579
Robinson, James; Guethlein, Lisbeth A; Cereb, Nezih et al. (2017) Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles. PLoS Genet 13:e1006862
Hilton, Hugo G; Blokhuis, Jeroen H; Guethlein, Lisbeth A et al. (2017) Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C. J Immunol 198:1961-1973
Béziat, Vivien; Hilton, Hugo G; Norman, Paul J et al. (2017) Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology. Immunology 150:248-264
Wu, Shuang; Majeed, Sophia R; Evans, Timothy M et al. (2016) Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A 113:9816-21
Horowitz, Amir; Djaoud, Zakia; Nemat-Gorgani, Neda et al. (2016) Class I HLA haplotypes form two schools that educate NK cells in different ways. Sci Immunol 1:
Norman, Paul J; Hollenbach, Jill A; Nemat-Gorgani, Neda et al. (2016) Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet 99:375-91

Showing the most recent 10 out of 77 publications