Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020264-14
Application #
2061163
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1987-12-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Floss, Heinz G (2006) Combinatorial biosynthesis--potential and problems. J Biotechnol 124:242-57
Yu, Yi; Bai, Linquan; Minagawa, Kazuyuki et al. (2005) Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008. Appl Environ Microbiol 71:5066-76
Floss, Heinz G; Yu, Tin-Wein (2005) Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev 105:621-32
Xu, Jun; Wan, Eva; Kim, Chang-Joon et al. (2005) Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. Microbiology 151:2515-28
Xu, Jun; Mahmud, Taifo; Floss, Heinz G (2003) Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. Arch Biochem Biophys 411:277-88
Arakawa, Kenji; Bowers, Simeon G; Michels, Benjamin et al. (2003) Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of isotopically labeled 2-epi-5-epi-valiolone analogs. Carbohydr Res 338:2075-82
Arakawa, Kenji; Muller, Rolf; Mahmud, Taifo et al. (2002) Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate. J Am Chem Soc 124:10644-5
Yu, T W; Muller, R; Muller, M et al. (2001) Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. J Biol Chem 276:12546-55
Tornus, D; Floss, H G (2001) Identification of four genes from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22 involved in the biosynthesis of L-rhodinose. J Antibiot (Tokyo) 54:91-101
McDonald, M; Mavrodi, D V; Thomashow, L S et al. (2001) Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid. J Am Chem Soc 123:9459-60

Showing the most recent 10 out of 44 publications