Abstract

The virus production core facility provides 4 fully equipped self contained cubicles with biohazard hoods and centrifuges. Centrifuges used in the large scale purification of HIV are contained in one cubicle. A common, central area provides for storage of media, cell lines and HIV. The biohazard safety and timely allocation of space is supervised by the responsible investigators and is subject to review of the biohazard Safety Officer and a laboratory assistant will be responsible for maintenance of the equipment and laboratory environment. HIV or its components will be produced in this facility and neutralization assays will be available to all investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI020671-08
Application #
3803408
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Goldstein, H; Pettoello-Mantovani, M; Katopodis, N F et al. (1996) SCID-hu mice: a model for studying disseminated HIV infection. Semin Immunol 8:223-31
Kollmann, T R; Pettoello-Mantovani, M; Katopodis, N F et al. (1996) Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver. Proc Natl Acad Sci U S A 93:3126-31
Kollmann, T R; Kim, A; Pettoello-Mantovani, M et al. (1995) Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 154:907-21
Kollmann, T R; Pettoello-Mantovani, M; Zhuang, X et al. (1994) Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. J Exp Med 179:513-22
Kollmann, T R; Kim, A; Zhuang, X et al. (1994) Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines. Proc Natl Acad Sci U S A 91:8032-6
Rubinstein, A; Goldstein, H; Pettoello-Mantovani, M et al. (1994) Preliminary results of V3 loop peptide-primary neutralizing domain conjugate phase 1 vaccine trail. AIDS Res Hum Retroviruses 10 Suppl 2:S149-53
Pettoello-Mantovani, M; Casadevall, A; Smarnworawong, P et al. (1994) Enhancement of HIV type 1 infectivity in vitro by capsular polysaccharide of Cryptococcus neoformans and Haemophilus influenzae. AIDS Res Hum Retroviruses 10:1079-87
Kollmann, T R; Goldstein, M M; Goldstein, H (1993) The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system. J Exp Med 177:821-32
Rubinstein, A; Goldstein, H; Calvelli, T et al. (1993) Maternofetal transmission of human immunodeficiency virus-1: the role of antibodies to the V3 primary neutralizing domain. Pediatr Res 33:S76-8;discussion S78-9
Suarez Jr, M A; Blanco, B; Brion, L P et al. (1993) A rapid test for the detection of human immunodeficiency virus antibodies in cord blood. J Pediatr 123:259-61

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