Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI021961-12
Application #
2061658
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1984-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Gabig, T G; Crean, C D; Mantel, P L et al. (1995) Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation. Blood 85:804-11
Graves, V; Gabig, T; McCarthy, L et al. (1992) Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils. Blood 80:776-87
Eklund, E A; Marshall, M; Gibbs, J B et al. (1991) Resolution of a low molecular weight G protein in neutrophil cytosol required for NADPH oxidase activation and reconstitution by recombinant Krev-1 protein. J Biol Chem 266:13964-70
Eklund, E A; Gabig, T G (1990) Purification and characterization of a lipid thiobis ester from human neutrophil cytosol that reversibly deactivates the O2- -generating NADPH oxidase. J Biol Chem 265:8426-30
Broxmeyer, H E; Cooper, S; Gabig, T (1989) The effects of oxidizing species derived from molecular oxygen on the proliferation in vitro of human granulocyte-macrophage progenitor cells. Ann N Y Acad Sci 554:177-84
Parkinson, J F; Gabig, T G (1988) Phagocyte NADPH-oxidase. Studies with flavin analogues as active site probes in triton X-100-solubilized preparations. J Biol Chem 263:8859-63
Akard, L P; English, D; Gabig, T G (1988) Rapid deactivation of NADPH oxidase in neutrophils: continuous replacement by newly activated enzyme sustains the respiratory burst. Blood 72:322-7
English, D; Debono, D J; Gabig, T G (1987) Relationship of phosphatidylinositol bisphosphate hydrolysis to calcium mobilization and functional activation in fluoride-treated neutrophils. J Clin Invest 80:145-53
Gabig, T G; English, D; Akard, L P et al. (1987) Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein. J Biol Chem 262:1685-90
English, D; Gabig, T G (1986) Differentiation of cellular processes involved in the induction and maintenance of stimulated neutrophil adherence. Blood 67:1314-22

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