Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022186-11
Application #
2061743
Study Section
Experimental Virology Study Section (EVR)
Project Start
1985-12-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Trobaugh, Derek W; Klimstra, William B (2017) Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses. Curr Opin Virol 23:30-34
Gardner, Christina L; Trobaugh, Derek W; Ryman, Kate D et al. (2016) Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System. Methods Mol Biol 1428:127-37
Burke, Crystal W; Gardner, Christina L; Steffan, Joshua J et al. (2009) Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses. Virology 395:121-32
Tesfay, Mulu Z; Yin, Jun; Gardner, Christina L et al. (2008) Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism. J Virol 82:2620-30
Ryman, Kate D; Meier, Kathryn C; Gardner, Christina L et al. (2007) Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons. Virology 368:273-85
Zhang, Yugen; Burke, Crystal W; Ryman, Kate D et al. (2007) Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol 81:11246-55
Ryman, Kate D; Gardner, Christina L; Meier, Kathryn C et al. (2007) Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease. J Gen Virol 88:518-29
Ryman, Kate D; Gardner, Christina L; Burke, Crystal W et al. (2007) Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses. J Virol 81:3563-73
Ossiboff, Robert J; Sheh, Alexander; Shotton, Justine et al. (2007) Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates. J Gen Virol 88:506-17
Klimstra, William B; Williams, Jacqueline C; Ryman, Kate D et al. (2005) Targeting Sindbis virus-based vectors to Fc receptor-positive cell types. Virology 338:9-21

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