Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022806-11
Application #
2061979
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1985-12-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Kowalski, Michael P; Pier, Gerald B (2004) Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. J Immunol 172:418-25
Cannon, Carolyn L; Kowalski, Michael P; Stopak, Kimberly S et al. (2003) Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol 29:188-97
Schroeder, T H; Reiniger, N; Meluleni, G et al. (2001) Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J Immunol 166:7410-8
Schroeder, T H; Zaidi, T; Pier, G B (2001) Lack of adherence of clinical isolates of Pseudomonas aeruginosa to asialo-GM(1) on epithelial cells. Infect Immun 69:719-29
Knirel, Y A; Bystrova, O V; Shashkov, A S et al. (2001) Structural analysis of the lipopolysaccharide core of a rough, cystic fibrosis isolate of Pseudomonas aeruginosa. Eur J Biochem 268:4708-19
Allewelt, M; Coleman, F T; Grout, M et al. (2000) Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread. Infect Immun 68:3998-4004
Goldberg, J B; Pier, G B (2000) The role of the CFTR in susceptibility to Pseudomonas aeruginosa infections in cystic fibrosis. Trends Microbiol 8:514-20
Pier, G B (2000) Role of the cystic fibrosis transmembrane conductance regulator in innate immunity to Pseudomonas aeruginosa infections. Proc Natl Acad Sci U S A 97:8822-8
Gerceker, A A; Zaidi, T; Marks, P et al. (2000) Impact of heterogeneity within cultured cells on bacterial invasion: analysis of Pseudomonas aeruginosa and Salmonella enterica serovar typhi entry into MDCK cells by using a green fluorescent protein-labelled cystic fibrosis transmembrane conductance reg Infect Immun 68:861-70
Parad, R B; Gerard, C J; Zurakowski, D et al. (1999) Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype. Infect Immun 67:4744-50

Showing the most recent 10 out of 29 publications