Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023262-15
Application #
6341563
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Voulgaropoulou, Frosso
Project Start
1985-08-01
Project End
2004-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
15
Fiscal Year
2001
Total Cost
$312,892
Indirect Cost
Name
University of Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
During, Russell L; Gibson, Bruce G; Li, Wei et al. (2007) Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation. EMBO J 26:2240-50
Zhang, Y; Vorobiev, Sergey M; Gibson, Bruce G et al. (2006) A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing. EMBO J 25:4458-67
Sidhu, Gurjit; Li, Wei; Laryngakis, Nicholas et al. (2005) Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation. J Biol Chem 280:11379-86
Larson, Laura; Arnaudeau, Serge; Gibson, Bruce et al. (2005) Gelsolin mediates calcium-dependent disassembly of Listeria actin tails. Proc Natl Acad Sci U S A 102:1921-6
During, Russell L; Li, Wei; Hao, Binghua et al. (2005) Anthrax lethal toxin paralyzes neutrophil actin-based motility. J Infect Dis 192:837-45
Parikh, Shefal S; Litherland, Sally A; Clare-Salzler, Michael J et al. (2003) CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection. Infect Immun 71:6582-90
Southwick, Frederick S; Li, Wei; Zhang, Fangliang et al. (2003) Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc. Cell Motil Cytoskeleton 54:41-55
Bubb, Michael R; Yarmola, Elena G; Gibson, Bruce G et al. (2003) Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function. J Biol Chem 278:24629-35
Zhang, Fangliang; Southwick, Frederick S; Purich, Daniel L (2002) Actin-based phagosome motility. Cell Motil Cytoskeleton 53:81-8
Witke, W; Li, W; Kwiatkowski, D J et al. (2001) Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. J Cell Biol 154:775-84

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