Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI023483-09A1
Application #
2062222
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1986-07-01
Project End
2001-05-31
Budget Start
1996-06-05
Budget End
1997-05-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Wong, G William; Stevens, Richard L (2005) Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases. Biochem Biophys Res Commun 336:579-84
Li, Lixin; Yang, Yi; Stevens, Richard L (2003) RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. J Biol Chem 278:4725-9
Li, Lixin; Yang, Yi; Stevens, Richard L (2002) Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors. Mol Immunol 38:1283-8
Yang, Yi; Li, Lixin; Wong, Guang W et al. (2002) RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demon J Biol Chem 277:25756-74
Qi, Jian Cheng; Stevens, Richard L; Wadley, Robert et al. (2002) IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1. J Immunol 168:4127-34
Wong, Guang W; Foster, Paul S; Yasuda, Shinsuke et al. (2002) Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer J Biol Chem 277:41906-15
Walsh, Jonathan C; DeKoter, Rodney P; Lee, Hyun Jun et al. (2002) Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity 17:665-76
Wong, G W; Li, L; Madhusudhan, M S et al. (2001) Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases. J Biol Chem 276:20648-58
Wong, G W; Yasuda, S; Madhusudhan, M S et al. (2001) Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. J Biol Chem 276:49169-82
Li, Y; Li, L; Wadley, R et al. (2001) Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood 97:3484-90

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