Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI024840-09A2
Application #
2062774
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-09-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Korchak, Helen M; Dorsey, Lindsay B; Li, Haiying et al. (2007) Selective roles for alpha-PKC in positive signaling for O-(2) generation and calcium mobilization but not elastase release in differentiated HL60 cells. Biochim Biophys Acta 1773:440-9
Lai, J-P; Ho, W Z; Kilpatrick, L E et al. (2006) Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Proc Natl Acad Sci U S A 103:7771-6
Kilpatrick, Laurie E; Sun, Shuang; Mackie, Demauri et al. (2006) Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2. J Leukoc Biol 80:1512-21
Kilpatrick, Laurie E; Sun, Shuang; Korchak, Helen M (2004) Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. Am J Physiol Cell Physiol 287:C633-42
Kilpatrick, Laurie E; Lee, Julia Y; Haines, Kathleen M et al. (2002) A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. Am J Physiol Cell Physiol 283:C48-57
Korchak, H M; Corkey, B E; Yaney, G C et al. (2001) Negative regulation of ligand-initiated Ca(2+) uptake by PKC-beta II in differentiated HL60 cells. Am J Physiol Cell Physiol 281:C514-23
Korchak, H M; Kilpatrick, L E (2001) Roles for beta II-protein kinase C and RACK1 in positive and negative signaling for superoxide anion generation in differentiated HL60 cells. J Biol Chem 276:8910-7
Korchak, H M; Kilpatrick, L E (2001) TNFalpha elicits association of PI 3-kinase with the p60TNFR and activation of PI 3-kinase in adherent neutrophils. Biochem Biophys Res Commun 281:651-6
Kilpatrick, L E; Song, Y H; Rossi, M W et al. (2000) Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. Am J Physiol Cell Physiol 279:C2011-8
Yaney, G C; Korchak, H M; Corkey, B E (2000) Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology 141:1989-98

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