Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026644-07
Application #
2063456
Study Section
Immunobiology Study Section (IMB)
Project Start
1988-08-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Sadra, Ali; Cinek, Tomas; Imboden, John B (2004) Translocation of CD28 to lipid rafts and costimulation of IL-2. Proc Natl Acad Sci U S A 101:11422-7
Chikuma, Shunsuke; Imboden, John B; Bluestone, Jeffrey A (2003) Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med 197:129-35
Cinek, T; Sadra, A; Imboden, J B (2000) Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol 164:8-May
Sadra, A; Cinek, T; Imboden, J B (2000) Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity. Anal Biochem 278:235-7
Sadra, A; Cinek, T; Arellano, J L et al. (1999) Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells. J Immunol 162:1966-73
Barz, C; Nagel, T; Truitt, K E et al. (1998) Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production. J Immunol 161:5366-72
Truitt, K E; Nagel, T; Suen, L F et al. (1996) Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J Immunol 156:4539-41
Truitt, K E; Shi, J; Gibson, S et al. (1995) CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J Immunol 155:4702-10
Truitt, K E; Hicks, C M; Imboden, J B (1994) Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med 179:1071-6
Truitt, K E; Mills, G B; Turck, C W et al. (1994) SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain. J Biol Chem 269:5937-43

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