Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI028419-07S1
Application #
2064450
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1989-09-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Stevens, David B; Gold, Daniel P; Sercarz, Eli E et al. (2002) The Wistar Kyoto (RT1(l)) rat is resistant to myelin basic protein-induced experimental autoimmune encephalomyelitis: comparison with the susceptible Lewis (RT1(l)) strain with regard to the MBP-directed CD4+ T cell repertoire and its regulation. J Neuroimmunol 126:25-36
Ria, F; van den Elzen, P; Madakamutil, L T et al. (2001) Molecular characterization of the T cell repertoire using immunoscope analysis and its possible implementation in clinical practice. Curr Mol Med 1:297-304
Quinn, A; McInerney, M F; Sercarz, E E (2001) MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity. J Immunol 167:1748-57
Quinn, A; Melo, M; Ethell, D et al. (2001) Relative resistance to nasally induced tolerance in non-obese diabetic mice but not other I-A(g7)-expressing mouse strains. Int Immunol 13:1321-33
Maverakis, E; van den Elzen, P; Sercarz, E E (2001) Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility. J Autoimmun 16:201-9
Moudgil, K D; Sercarz, E E (2000) The self-directed T cell repertoire: its creation and activation. Rev Immunogenet 2:26-37
Borghans, J A; De Boer, R J; Sercarz, E et al. (1998) T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model. J Immunol 161:1087-93
Drakesmith, H; O'Neil, D; Schneider, S C et al. (1998) In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen. Proc Natl Acad Sci U S A 95:14903-8
Sercarz, E E (1998) Immune focusing vs diversification and their connection to immune regulation. Immunol Rev 164:5-10
Kumar, V; Tabibiazar, R; Geysen, H M et al. (1995) Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls murine experimental autoimmune encephalomyelitis. J Immunol 154:1941-50

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