This proposal is part of an Interactive Research Project Grant (IRPG) which is being submitted with Dr. Raymond F. Schinazi. Specifically, his laboratory will evaluate all compounds that are prepared under this application. As leads develop, these investigators will work collaboratively to optimize the antiviral profile of the compounds. The project will focus on the continued development of practical methodology for the synthesis of purine and pyrimidine nucleoside analogues. Specifically, these studies include the development of methodology for intramolecular 3'- and 5'-transfer glycosylations, the selective fluorination of nucleoside analogues, the diastereoselective transglycosylation of lactol derivatives with nucleoside base surrogates, the diastereoselective additions of purine and pyrimidine bases to glycals, and combinatorial synthesis of nucleoside analogue libraries. The project will also include the continued synthesis and evaluation of selected D- and L-nucleoside analogue targets which possess favorable anti-HIV/HBV profiles. These include dideoxy purine and pyrimidine nucleoside analogues with an emphasis on fluorinated derivatives, heteranucleosides; 6-substituted pyrimidine nucleoside analogues; phosphorylated nucleoside analogues, including phospholipid conjugates which target selected organs of tissues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028731-09
Application #
2671969
Study Section
Special Emphasis Panel (ZRG5-AAR (04))
Project Start
1989-07-01
Project End
2002-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Emory University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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