Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028799-07
Application #
2064633
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1990-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Yu, Yang; Maroney, Patricia A; Denker, John A et al. (2008) Dynamic regulation of alternative splicing by silencers that modulate 5'splice site competition. Cell 135:1224-36
Romfo, C M; Maroney, P A; Wu, S et al. (2001) 3' splice site recognition in nematode trans-splicing involves enhancer-dependent recruitment of U2 snRNP. RNA 7:785-92
Maroney, P A; Romfo, C M; Nilsen, T W (2000) Functional recognition of 5' splice site by U4/U6.U5 tri-snRNP defines a novel ATP-dependent step in early spliceosome assembly. Mol Cell 6:317-28
Maroney, P A; Yu, Y T; Jankowska, M et al. (1996) Direct analysis of nematode cis- and trans-spliceosomes: a functional role for U5 snRNA in spliced leader addition trans-splicing and the identification of novel Sm snRNPs. RNA 2:735-45
Yu, Y T; Maroney, P A; Darzynkiwicz, E et al. (1995) U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone. RNA 1:46-54
Maroney, P A; Denker, J A; Darzynkiewicz, E et al. (1995) Most mRNAs in the nematode Ascaris lumbricoides are trans-spliced: a role for spliced leader addition in translational efficiency. RNA 1:714-23
Denker, J A; Nilsen, T W (1994) Characterization of a DNA-binding factor that recognizes the 22-base pair trans-spliced leader sequence in Ascaris lumbricoides. Mol Biochem Parasitol 66:139-42
Shambaugh, J D; Hannon, G E; Nilsen, T W (1994) The spliceosomal U small nuclear RNAs of Ascaris lumbricoides. Mol Biochem Parasitol 64:349-52
Hannon, G E; Hannon, G J; Maroney, P A et al. (1994) Transcription of a nematode U1 small nuclear RNA in vitro. 3'-end formation requires cis-acting elements within the coding sequence. J Biol Chem 269:12387-90
Nilsen, T W (1993) Trans-splicing of nematode premessenger RNA. Annu Rev Microbiol 47:413-40

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