Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI029952-05
Application #
2065329
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1991-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Pinho-Ribeiro, Felipe A; Baddal, Buket; Haarsma, Rianne et al. (2018) Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell 173:1083-1097.e22
Velarde, Jorge J; O'Seaghdha, Maghnus; Baddal, Buket et al. (2017) Binding of NAD+-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus. MBio 8:
Hancz, Dóra; Westerlund, Elsa; Bastiat-Sempe, Benedicte et al. (2017) Inhibition of Inflammasome-Dependent Interleukin 1? Production by Streptococcal NAD+-Glycohydrolase: Evidence for Extracellular Activity. MBio 8:
Sharma, Onkar; O'Seaghdha, Maghnus; Velarde, Jorge J et al. (2016) NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus. PLoS Pathog 12:e1005468
Velarde, Jorge J; Ashbaugh, Melissa; Wessels, Michael R (2014) The human antimicrobial peptide LL-37 binds directly to CsrS, a sensor histidine kinase of group A Streptococcus, to activate expression of virulence factors. J Biol Chem 289:36315-24
Jiang, Shengmei; Wessels, Michael R (2014) BsaB, a novel adherence factor of group B Streptococcus. Infect Immun 82:1007-16
O'Seaghdha, Maghnus; Wessels, Michael R (2013) Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing. PLoS Pathog 9:e1003394
Love, John F; Tran-Winkler, Hien J; Wessels, Michael R (2012) Vitamin D and the human antimicrobial peptide LL-37 enhance group a streptococcus resistance to killing by human cells. MBio 3:
Logsdon, Lauren K; Hakansson, Anders P; Cortes, Guadalupe et al. (2011) Streptolysin O inhibits clathrin-dependent internalization of group A Streptococcus. MBio 2:e00332-10
Tran-Winkler, Hien J; Love, John F; Gryllos, Ioannis et al. (2011) Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus. PLoS Pathog 7:e1002361

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