Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI030492-08S1
Application #
2613975
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1991-01-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
8
Fiscal Year
1997
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Genetics
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Galán, Jorge E; Waksman, Gabriel (2018) Protein-Injection Machines in Bacteria. Cell 172:1306-1318
Park, Donghyun; Lara-Tejero, Maria; Waxham, M Neal et al. (2018) Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography. Elife 7:
Zhang, Yongdeng; Lara-Tejero, María; Bewersdorf, Jörg et al. (2017) Visualization and characterization of individual type III protein secretion machines in live bacteria. Proc Natl Acad Sci U S A 114:6098-6103
Hu, Bo; Lara-Tejero, Maria; Kong, Qingke et al. (2017) In Situ Molecular Architecture of the Salmonella Type III Secretion Machine. Cell 168:1065-1074.e10
Tsou, Lun K; Lara-Tejero, María; RoseFigura, Jordan et al. (2016) Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. J Am Chem Soc 138:2209-18
Kato, Junya; Lefebre, Matthew; Galán, Jorge E (2015) Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase. J Bacteriol 197:3007-14
Monjarás Feria, Julia V; Lefebre, Matthew D; Stierhof, York-Dieter et al. (2015) Role of autocleavage in the function of a type III secretion specificity switch protein in Salmonella enterica serovar Typhimurium. MBio 6:e01459-15
Lefebre, Matthew D; Galán, Jorge E (2014) The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proc Natl Acad Sci U S A 111:817-22
Rathinavelan, Thenmalarchelvi; Lara-Tejero, Maria; Lefebre, Matthew et al. (2014) NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. J Mol Biol 426:2958-69
Galán, Jorge E; Lara-Tejero, Maria; Marlovits, Thomas C et al. (2014) Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Annu Rev Microbiol 68:415-38

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