Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031077-05
Application #
2066086
Study Section
Special Emphasis Panel (ZRG5-BM-2 (01))
Project Start
1992-02-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Seattle Biomedical Research Institute
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98109
Jensen, Bryan C; Kifer, Charles T; Parsons, Marilyn (2011) Trypanosoma brucei: Two mitogen activated protein kinase kinases are dispensable for growth and virulence of the bloodstream form. Exp Parasitol 128:250-5
Chou, Seemay; Jensen, Bryan C; Parsons, Marilyn et al. (2010) The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46. J Biol Chem 285:22075-81
Worthen, Christal; Jensen, Bryan C; Parsons, Marilyn (2010) Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei. PLoS Negl Trop Dis 4:e678
Flaspohler, John A; Jensen, Bryan C; Saveria, Tracy et al. (2010) A novel protein kinase localized to lipid droplets is required for droplet biogenesis in trypanosomes. Eukaryot Cell 9:1702-10
Jensen, Bryan C; Sivam, Dhileep; Kifer, Charles T et al. (2009) Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics 10:482
Jensen, Bryan C; Kifer, Charles T; Brekken, Deirdre L et al. (2007) Characterization of protein kinase CK2 from Trypanosoma brucei. Mol Biochem Parasitol 151:28-40
Parsons, Marilyn; Worthey, Elizabeth A; Ward, Pauline N et al. (2005) Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi. BMC Genomics 6:127
Jensen, Bryan C; Brekken, Deirdre L; Randall, Amber C et al. (2005) Species specificity in ribosome biogenesis: a nonconserved phosphoprotein is required for formation of the large ribosomal subunit in Trypanosoma brucei. Eukaryot Cell 4:30-5
Naula, Christina; Parsons, Marilyn; Mottram, Jeremy C (2005) Protein kinases as drug targets in trypanosomes and Leishmania. Biochim Biophys Acta 1754:151-9
El-Sayed, Najib M; Myler, Peter J; Bartholomeu, Daniella C et al. (2005) The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science 309:409-15

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