Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI032248-04
Application #
2067147
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Pathology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Pal, Sukumar; Tatarenkova, Olga V; de la Maza, Luis M (2015) A vaccine formulated with the major outer membrane protein can protect C3H/HeN, a highly susceptible strain of mice, from a Chlamydia muridarum genital challenge. Immunology 146:432-43
Al-Kuhlani, Mufadhal; Rothschild, James; Rothchild, James et al. (2014) TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans. PLoS One 9:e93939
Pal, Sukumar; de la Maza, Luis M (2013) Mechanism of T-cell mediated protection in newborn mice against a Chlamydia infection. Microbes Infect 15:607-14
Tifrea, Delia F; Sun, Guifeng; Pal, Sukumar et al. (2011) Amphipols stabilize the Chlamydia major outer membrane protein and enhance its protective ability as a vaccine. Vaccine 29:4623-31
Pal, Sukumar; Tatarenkova, Olga; de la Maza, Luis M (2010) Maternal immunity partially protects newborn mice against a Chlamydia trachomatis intranasal challenge. J Reprod Immunol 86:151-7
Pal, Sukumar; Sarcon, Annahita K; de la Maza, Luis M (2010) A new murine model for testing vaccines against genital Chlamydia trachomatis infections in males. Vaccine 28:7606-12
Kari, Laszlo; Whitmire, William M; Crane, Deborah D et al. (2009) Chlamydia trachomatis native major outer membrane protein induces partial protection in nonhuman primates: implication for a trachoma transmission-blocking vaccine. J Immunol 182:8063-70
Cai, Sumin; He, Feng; Samra, Hardeep S et al. (2009) Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Mol Pharm 6:1553-61
Cheng, Chunmei; Bettahi, Ilham; Cruz-Fisher, Maria I et al. (2009) Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxin. Vaccine 27:6239-46
Sun, Guifeng; Pal, Sukumar; Weiland, Joseph et al. (2009) Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein. Vaccine 27:5020-5

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