Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI032592-04A1
Application #
2067500
Study Section
Immunobiology Study Section (IMB)
Project Start
1993-05-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kobayashi, Takashi; Kim, Tae Soo; Jacob, Anand et al. (2009) TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS One 4:e4736
Stadanlick, Jason E; Kaileh, Mary; Karnell, Fredrick G et al. (2008) Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling. Nat Immunol 9:1379-87
Brezski, Randall J; Monroe, John G (2007) B cell antigen receptor-induced Rac1 activation and Rac1-dependent spreading are impaired in transitional immature B cells due to levels of membrane cholesterol. J Immunol 179:4464-72
Grande, S M; Katz, E; Crowley, J E et al. (2006) Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells. Oncogene 25:2748-57
Karnell, Fredrick G; Brezski, Randall J; King, Leslie B et al. (2005) Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling. J Biol Chem 280:25621-8
Skalet, Alison H; Isler, Jennifer A; King, Leslie B et al. (2005) Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. J Biol Chem 280:39762-71
Fuentes-Panana, Ezequiel M; Bannish, Gregory; van der Voort, Dustin et al. (2005) Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization. J Immunol 174:1245-52
Chung, James B; Wells, Andrew D; Adler, Scott et al. (2003) Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. J Immunol 171:1758-67
Chung, James B; Sater, Richard A; Fields, Michele L et al. (2002) CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals. Int Immunol 14:157-66
Chiang, M Y; Monroe, J G (2001) Role for transcription Pax5A factor in maintaining commitment to the B cell lineage by selective inhibition of granulocyte-macrophage colony-stimulating factor receptor expression. J Immunol 166:6091-8

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