Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI032596-04
Application #
2067507
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1993-01-01
Project End
1997-11-30
Budget Start
1996-01-01
Budget End
1997-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Lai, Zengzu; Schreiber, John R (2011) Outer membrane protein complex of Meningococcus enhances the antipolysaccharide antibody response to pneumococcal polysaccharide-CRM??? conjugate vaccine. Clin Vaccine Immunol 18:724-9
Kaur, Kulwant; Chowdhury, Shimul; Greenspan, Neil S et al. (2007) Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood 110:2948-54
Lai, Zengzu; Kimmel, Rhonda; Petersen, Sheryl et al. (2005) Multi-valent human monoclonal antibody preparation against Pseudomonas aeruginosa derived from transgenic mice containing human immunoglobulin loci is protective against fatal pseudomonas sepsis caused by multiple serotypes. Vaccine 23:3264-71
Latz, Eicke; Franko, Jennifer; Golenbock, Douglas T et al. (2004) Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. J Immunol 172:2431-8
Maaser, Christian; Housley, Michael P; Iimura, Mitsutoshi et al. (2004) Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun 72:3315-24
Leonard, Ethan G; Canaday, David H; Harding, Clifford V et al. (2003) Antigen processing of the heptavalent pneumococcal conjugate vaccine carrier protein CRM(197) differs depending on the serotype of the attached polysaccharide. Infect Immun 71:4186-9
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Kamboj, Kulwant K; Kirchner, H Lester; Kimmel, Rhonda et al. (2003) Significant variation in serotype-specific immunogenicity of the seven-valent Streptococcus pneumoniae capsular polysaccharide-CRM197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein. J Infect Dis 187:1629-38
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McLay, John; Leonard, Ethan; Petersen, Sheryl et al. (2002) Gamma 3 gene-disrupted mice selectively deficient in the dominant IgG subclass made to bacterial polysaccharides. II. Increased susceptibility to fatal pneumococcal sepsis due to absence of anti-polysaccharide IgG3 is corrected by induction of anti-polysa J Immunol 168:3437-43

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