Abstract

The investigator has identified a novel member of the TNF ligand family, termed LIGHT, which interacts with HVEM (herpesvirus entry mediator), formerly an orphan receptor of the TNF receptor superfamily. He advances arguments that suggest that the interaction between LIGHT and HVEM, as well as the LT-beta (LT-b) receptor, may have important physiological consequences. He intends to investigate the connection between LIGHT and lymphoid development, as well as viral pathogenesis, given that HVEM serves as a receptor for glycoprotein D of Herpes simplex virus type I.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI033068-06
Application #
2699948
Study Section
Allergy and Immunology Study Section (ALY)
Program Officer
Finerty, John F
Project Start
1994-08-01
Project End
2003-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Šedý, John; Bekiaris, Vasileios; Ware, Carl F (2015) Tumor necrosis factor superfamily in innate immunity and inflammation. Cold Spring Harb Perspect Biol 7:a016279
Correa, Ricardo G; Krajewska, Maryla; Ware, Carl F et al. (2014) The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget 5:1666-82
Gommerman, Jennifer L; Browning, Jeffrey L; Ware, Carl F (2014) The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity. Cytokine Growth Factor Rev 25:139-45
Allen, Sariah J; Rhode-Kurnow, Antje; Mott, Kevin R et al. (2014) Interactions between herpesvirus entry mediator (TNFRSF14) and latency-associated transcript during herpes simplex virus 1 latency. J Virol 88:1961-71
Šedý, John R; Bjordahl, Ryan L; Bekiaris, Vasileios et al. (2013) CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells. J Immunol 191:828-36
Flynn, Rachel; Hutchinson, Tarun; Murphy, Kenneth M et al. (2013) CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA. PLoS One 8:e77991
Nemcovicova, Ivana; Benedict, Chris A; Zajonc, Dirk M (2013) Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions. PLoS Pathog 9:e1003224
Croft, Michael; Benedict, Chris A; Ware, Carl F (2013) Clinical targeting of the TNF and TNFR superfamilies. Nat Rev Drug Discov 12:147-68
Bjordahl, Ryan L; Steidl, Christian; Gascoyne, Randy D et al. (2013) Lymphotoxin network pathways shape the tumor microenvironment. Curr Opin Immunol 25:222-9
Smith, Wendell; Tomasec, Peter; Aicheler, Rebecca et al. (2013) Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host Microbe 13:324-35

Showing the most recent 10 out of 57 publications