Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033106-03
Application #
2068093
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1994-09-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Georgia
Department
Zoology
Type
Schools of Arts and Sciences
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Rosenberg, Charles S; Zhang, Weibo; Bustamante, Juan M et al. (2016) Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells. Infect Immun 84:2627-38
Collins, Matthew H; Craft, Julie M; Bustamante, Juan M et al. (2011) Oral exposure to Trypanosoma cruzi elicits a systemic CD8? T cell response and protection against heterotopic challenge. Infect Immun 79:3397-406
Bustamante, Juan M; Tarleton, Rick L (2011) Methodological advances in drug discovery for Chagas disease. Expert Opin Drug Discov 6:653-661
Canavaci, Adriana M C; Bustamante, Juan M; Padilla, Angel M et al. (2010) In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds. PLoS Negl Trop Dis 4:e740
Martin, Diana L; Murali-Krishna, Kaja; Tarleton, Rick L (2010) Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling. Infect Immun 78:3154-9
Rosenberg, Charles S; Martin, Dianya L; Tarleton, Rick L (2010) CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance. J Immunol 185:560-8
Padilla, Angel M; Bustamante, Juan M; Tarleton, Rick L (2009) CD8+ T cells in Trypanosoma cruzi infection. Curr Opin Immunol 21:385-90
Padilla, Angel M; Simpson, Laura J; Tarleton, Rick L (2009) Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection. J Immunol 183:1245-52
Bustamante, Juan M; Bixby, Lisa M; Tarleton, Rick L (2008) Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat Med 14:542-50
Bixby, Lisa M; Tarleton, Rick L (2008) Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J Immunol 181:2644-50

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