Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI033170-04A2
Application #
2068163
Study Section
Biochemistry Study Section (BIO)
Project Start
1992-08-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Kumarasiri, Malika; Llarrull, Leticia I; Borbulevych, Oleg et al. (2012) An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D ?-lactamases. J Biol Chem 287:8232-41
Borbulevych, Oleg; Kumarasiri, Malika; Wilson, Brian et al. (2011) Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus. J Biol Chem 286:31466-72
Llarrull, Leticia I; Toth, Marta; Champion, Matthew M et al. (2011) Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance. J Biol Chem 286:38148-58
Llarrull, Leticia I; Prorok, Mary; Mobashery, Shahriar (2010) Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. Biochemistry 49:7975-7
Lemaire, Sandrine; Fuda, Cosimo; Van Bambeke, Francoise et al. (2008) Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a. J Biol Chem 283:12769-76
Totir, Monica A; Cha, Jooyoung; Ishiwata, Akihiro et al. (2008) Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. Biochemistry 47:4094-101
Meroueh, Samy O; Bencze, Krisztina Z; Hesek, Dusan et al. (2006) Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A 103:4404-9
Fisher, Jed F; Meroueh, Samy O; Mobashery, Shahriar (2005) Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity. Chem Rev 105:395-424
Thomas, Veena L; Golemi-Kotra, Dasantila; Kim, Choonkeun et al. (2005) Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. Biochemistry 44:9330-8
Golemi-Kotra, Dasantila; Meroueh, Samy O; Kim, Choonkeun et al. (2004) The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins. J Biol Chem 279:34665-73

Showing the most recent 10 out of 16 publications