Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033481-04
Application #
2068508
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1993-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Bobrov, Alexander G; Kirillina, Olga; Fosso, Marina Y et al. (2017) Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice. Metallomics 9:757-772
Perry, Robert D; Bobrov, Alexander G; Fetherston, Jacqueline D (2015) The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis. Metallomics 7:965-78
Bobrov, Alexander G; Kirillina, Olga; Fetherston, Jacqueline D et al. (2014) The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice. Mol Microbiol 93:759-75
Perry, Robert D; Craig, Susannah K; Abney, Jennifer et al. (2012) Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis. Microbiology 158:804-15
Perry, Robert D; Bobrov, Alexander G; Kirillina, Olga et al. (2012) Yersinia pestis transition metal divalent cation transporters. Adv Exp Med Biol 954:267-79
Fetherston, Jacqueline D; Mier Jr, Ildefonso; Truszczynska, Helena et al. (2012) The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague. Infect Immun 80:3880-91
Perry, Robert D; Fetherston, Jacqueline D (2011) Yersiniabactin iron uptake: mechanisms and role in Yersinia pestis pathogenesis. Microbes Infect 13:808-17
Fetherston, Jacqueline D; Kirillina, Olga; Bobrov, Alexander G et al. (2010) The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. Infect Immun 78:2045-52
Miller, M Clarke; Fetherston, Jacqueline D; Pickett, Carol L et al. (2010) Reduced synthesis of the Ybt siderophore or production of aberrant Ybt-like molecules activates transcription of yersiniabactin genes in Yersinia pestis. Microbiology 156:2226-38
Desrosiers, Daniel C; Bearden, Scott W; Mier Jr, Ildefonso et al. (2010) Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence. Infect Immun 78:5163-77

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