Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034039-04
Application #
2069118
Study Section
Virology Study Section (VR)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Wang, Die; de Weerd, Nicole A; Willard, Belinda et al. (2017) Auto-phosphorylation Represses Protein Kinase R Activity. Sci Rep 7:44340
Irving, Aaron T; Wang, Die; Vasilevski, Oliver et al. (2012) Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity 36:795-806
Xu, Dakang; Holko, Michelle; Sadler, Anthony J et al. (2009) Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity 30:802-16
Irving, Aaron; Williams, Bryan Rg (2009) Latest advances in innate antiviral defence. F1000 Biol Rep 1:22
Sadler, Anthony J; Latchoumanin, Olivier; Hawkes, David et al. (2009) An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog 5:e1000311
Gantier, Michael P; Tong, Stephen; Behlke, Mark A et al. (2008) TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J Immunol 180:2117-24
Chakrabarti, Arindam; Sadler, Anthony J; Kar, Niladri et al. (2008) Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA. J Biol Chem 283:25132-9
Zamanian-Daryoush, Maryam; Marques, Joao T; Gantier, Michael P et al. (2008) Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells. J Interferon Cytokine Res 28:221-33
Sadler, Anthony J; Williams, Bryan R G (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559-68
Gantier, Michael P; Williams, Bryan R G (2007) The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev 18:363-71

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