Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI035237-03S1
Application #
2070763
Study Section
Special Emphasis Panel (SRC (36))
Project Start
1993-09-30
Project End
1997-06-30
Budget Start
1995-09-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mcgill University
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
H3 0-G4
Kong, Xiao-Fei; Martinez-Barricarte, Ruben; Kennedy, James et al. (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol 19:973-985
Fodil, Nassima; Langlais, David; Gros, Philippe (2016) Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection. Trends Immunol 37:126-140
Langlais, David; Barreiro, Luis B; Gros, Philippe (2016) The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med 213:585-603
Torre, Sabrina; Faucher, Sebastien P; Fodil, Nassima et al. (2015) THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infect Immun 83:759-68
Zhang, Xianqin; Bogunovic, Dusan; Payelle-Brogard, Béatrice et al. (2015) Human intracellular ISG15 prevents interferon-?/? over-amplification and auto-inflammation. Nature 517:89-93
Kennedy, James M; Fodil, Nassima; Torre, Sabrina et al. (2014) CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med 211:2519-35
Salem, Sandra; Langlais, David; Lefebvre, François et al. (2014) Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation. Blood 124:1894-904
Salem, Sandra; Gao, Chan; Li, Ailian et al. (2014) A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism. J Cell Mol Med 18:1588-98
Fodil, Nassima; Langlais, David; Moussa, Peter et al. (2014) Specific dysregulation of IFN? production by natural killer cells confers susceptibility to viral infection. PLoS Pathog 10:e1004511
Dauphinee, S M; Richer, E; Eva, M M et al. (2014) Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes Immun 15:282-92

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