Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035947-03
Application #
2071937
Study Section
Special Emphasis Panel (SRC (83))
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Manukyan, Maria; Nalbant, Perihan; Luxen, Sylvia et al. (2009) RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol 182:3522-9
Maroto, B; Ye, M B; von Lohneysen, K et al. (2008) P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene 27:4900-8
Ruse, Monica; Knaus, Ulla G (2006) New players in TLR-mediated innate immunity: PI3K and small Rho GTPases. Immunol Res 34:33-48
Martyn, Kendra D; Kim, Moon-Ju; Quinn, Mark T et al. (2005) p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood 106:3962-9
Yamauchi, Akira; Marchal, Christophe C; Molitoris, Jason et al. (2005) Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem 280:953-64
Price, Marianne O; Atkinson, Simon J; Knaus, Ulla G et al. (2002) Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem 277:19220-8
Price, Marianne O; McPhail, Linda C; Lambeth, J David et al. (2002) Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood 99:2653-61
Wen, Y; Gu, J; Knaus, U G et al. (2000) Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase. Biochem J 349:481-7
Knaus, U G; Wang, Y; Reilly, A M et al. (1998) Structural requirements for PAK activation by Rac GTPases. J Biol Chem 273:21512-8
Bokoch, G M; Wang, Y; Bohl, B P et al. (1996) Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem 271:25746-9

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