Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036938-07
Application #
6510561
Study Section
Special Emphasis Panel (ZRG1-SSS-4 (10))
Program Officer
Johnson, David R
Project Start
1995-06-01
Project End
2002-07-02
Budget Start
2002-07-01
Budget End
2002-07-02
Support Year
7
Fiscal Year
2002
Total Cost
$1
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Chan, Derek V; Sharma, Rahul; Ju, Chiao-Ying A et al. (2013) A recombinant scFv-FasLext as a targeting cytotoxic agent against human Jurkat-Ras cancer. J Biomed Sci 20:16
Sharma, Rahul; Zheng, Lingjie; Deshmukh, Umesh S et al. (2007) A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis. J Immunol 178:1251-5
Sung, Sun-Sang J; Fu, Shu Man; Rose Jr, C Edward et al. (2006) A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol 176:2161-72
Sharma, R; Zheng, L; Guo, X et al. (2006) Novel animal models for Sjogren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice. J Autoimmun 27:289-96
Jodo, Satoshi; Pidiyar, Vyankatesh J; Xiao, Sheng et al. (2005) Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicity. J Immunol 174:4470-4
Xiao, Sheng; Deshmukh, Umesh S; Jodo, Satoshi et al. (2004) Novel negative regulator of expression in Fas ligand (CD178) cytoplasmic tail: evidence for translational regulation and against Fas ligand retention in secretory lysosomes. J Immunol 173:5095-102
Xiao, Sheng; Zhang, Xingmin; Mann, Koren K et al. (2004) Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells. Int Immunol 16:759-66
Jodo, Satoshi; Kung, John T; Xiao, Sheng et al. (2003) Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure. J Biol Chem 278:7553-7
Xiao, Sheng; Sung, Sun-Sang J; Fu, Shu Man et al. (2003) Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death. J Biol Chem 278:52730-8
Xiao, Sheng; Jodo, Satoshi; Sung, Sun-Sang J et al. (2002) A novel signaling mechanism for soluble CD95 ligand. Synergy with anti-CD95 monoclonal antibodies for apoptosis and NF-kappaB nuclear translocation. J Biol Chem 277:50907-13

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