Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI041108-08
Application #
6827869
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Program Officer
Peters, Kent
Project Start
1997-12-01
Project End
2007-11-30
Budget Start
2004-09-01
Budget End
2004-11-30
Support Year
8
Fiscal Year
2004
Total Cost
$304,157
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
073826000
City
Boston
State
MA
Country
United States
Zip Code
02114
McBride, Shonna M; Coburn, Phillip S; Baghdayan, Arto S et al. (2009) Genetic variation and evolution of the pathogenicity island of Enterococcus faecalis. J Bacteriol 191:3392-402
Cox, Christopher R; Gilmore, Michael S (2007) Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis. Infect Immun 75:1565-76
Spoering, Amy L; Gilmore, Michael S (2006) Quorum sensing and DNA release in bacterial biofilms. Curr Opin Microbiol 9:133-7
Cox, Christopher R; Coburn, Phillip S; Gilmore, Michael S (2005) Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells. Curr Protein Pept Sci 6:77-84
Engelbert, Michael; Gilmore, Michael S (2005) Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. Invest Ophthalmol Vis Sci 46:2479-86
Coburn, Phillip S; Pillar, Christopher M; Jett, Bradley D et al. (2004) Enterococcus faecalis senses target cells and in response expresses cytolysin. Science 306:2270-2
Engelbert, Michael; Mylonakis, Eleftherios; Ausubel, Frederick M et al. (2004) Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis. Infect Immun 72:3628-33
Shankar, Nathan; Coburn, Phillip; Pillar, Chris et al. (2004) Enterococcal cytolysin: activities and association with other virulence traits in a pathogenicity island. Int J Med Microbiol 293:609-18
Pillar, Christopher M; Gilmore, Michael S (2004) Enterococcal virulence--pathogenicity island of E. Faecalis. Front Biosci 9:2335-46
Rumpel, Sigrun; Razeto, Adelia; Pillar, Chris M et al. (2004) Structure and DNA-binding properties of the cytolysin regulator CylR2 from Enterococcus faecalis. EMBO J 23:3632-42

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