Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI044432-04
Application #
6511136
Study Section
Special Emphasis Panel (ZRG1-IMS (02))
Program Officer
Plaut, Marshall
Project Start
1999-07-01
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
4
Fiscal Year
2002
Total Cost
$432,719
Indirect Cost
Name
Immune Disease Institute, Inc.
Department
Type
DUNS #
115524410
City
Boston
State
MA
Country
United States
Zip Code
02115
Tsagaratou, Ageliki; González-Avalos, Edahí; Rautio, Sini et al. (2017) TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells. Nat Immunol 18:45-53
Lio, Chan-Wang; Zhang, Jiayuan; González-Avalos, Edahí et al. (2016) Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility. Elife 5:
Äijö, Tarmo; Huang, Yun; Mannerström, Henrik et al. (2016) A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways. Genome Biol 17:49
Äijö, Tarmo; Yue, Xiaojing; Rao, Anjana et al. (2016) LuxGLM: a probabilistic covariate model for quantification of DNA methylation modifications with complex experimental designs. Bioinformatics 32:i511-i519
Yue, Xiaojing; Trifari, Sara; Äijö, Tarmo et al. (2016) Control of Foxp3 stability through modulation of TET activity. J Exp Med 213:377-97
Balasubramani, Anand; Larjo, Antti; Bassein, Jed A et al. (2015) Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nat Commun 6:7307
Ko, Myunggon; An, Jungeun; Pastor, William A et al. (2015) TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunol Rev 263:6-21
Ko, Myunggon; An, Jungeun; Rao, Anjana (2015) DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Curr Opin Cell Biol 37:91-101
Kang, Jinsuk; Lienhard, Matthias; Pastor, William A et al. (2015) Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A 112:E4236-45
An, Jungeun; González-Avalos, Edahí; Chawla, Ashu et al. (2015) Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun 6:10071

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