Prostaglandins and Ion Transport Across Renal Tubules

Stokes, John B.

Abstract

The proposed work will investigate the effects of endogenous and exogenous prostaglandins on Na and water flow across the isolated perfused rabbit cortical collecting tubule. Arachidonic acid and meclofenamate will be used to stimulate and inhibit respectively prostaglandin production in cells during perfusion. The effects of prostaglandin E2 and F2 alpha on Na and C1 transport across the medullary thick ascending limb of Henle's loop will also be evaluated.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
• Type: Research Project (R01)
• Project #: 5R01AM025231-08
• Application #: 3151477
• Study Section: General Medicine B Study Section (GMB)
• Project Start: 1978-08-01
• Project End: 1986-07-31
• Budget Start: 1985-08-01
• Budget End: 1986-07-31
• Support Year: 8
• Fiscal Year: 1985

Institution

• Name: University of Iowa
• Type: Schools of Medicine
• DUNS #: 041294109
• City: Iowa City
• State: IA
• Country: United States
• Zip Code: 52242

Publications

Stokes, J B; Grupp, C; Kinne, R K (1987) Purification of rat papillary collecting duct cells: functional and metabolic assessment. Am J Physiol 253:F251-62

Schuster, V L; Stokes, J B (1987) Chloride transport by the cortical and outer medullary collecting duct. Am J Physiol 253:F203-12

Tago, K; Warden, D H; Schuster, V L et al. (1986) Effects of inhibitors of Cl conductance on Cl self-exchange in rabbit cortical collecting tubule. Am J Physiol 251:F1009-17

Tago, K; Schuster, V L; Stokes, J B (1986) Stimulation of chloride transport by HCO3-CO2 in rabbit cortical collecting tubule. Am J Physiol 251:F49-56

Tago, K; Schuster, V L; Stokes, J B (1986) Regulation of chloride self exchange by cAMP in cortical collecting tubule. Am J Physiol 251:F40-8

Stokes, J B (1986) Patterns of K+ permeation following inhibition of Na+ transport in rabbit cortical collecting tubule. Am J Physiol 250:F120-6

Schuster, V L (1985) Cyclic adenosine monophosphate-stimulated bicarbonate secretion in rabbit cortical collecting tubules. J Clin Invest 75:2056-64

Stokes 3rd, J B (1985) Modulation of vasopressin-induced water permeability of the cortical collecting tubule by endogenous and exogenous prostaglandins. Miner Electrolyte Metab 11:240-8

Stokes, J B (1985) Mineralocorticoid effect on K+ permeability of the rabbit cortical collecting tubule. Kidney Int 28:640-5