Abstract

The intent is to study the biologic function and metabolism of side chain cleaved products of 1 alpha, 25-dihydroxyvitamin D3. The goal is to determine whether these are excretory products or products with significant biological activity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM025409-07
Application #
3151497
Study Section
General Medicine B Study Section (GMB)
Project Start
1979-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Calvo, M S; Kumar, R; Heath 3rd, H (1988) Elevated secretion and action of serum parathyroid hormone in young adults consuming high phosphorus, low calcium diets assembled from common foods. J Clin Endocrinol Metab 66:823-9
Shultz, T D; Kumar, R (1987) Effect of cortisol on [3H] 1,25-dihydroxyvitamin D3 uptake and 1,25-dihydroxyvitamin D3-induced DNA-dependent RNA polymerase activity in chick intestinal cells. Calcif Tissue Int 40:224-30
Gross, M D; Nelsestuen, G L; Kumar, R (1987) Observations on the binding of lanthanides and calcium to vitamin D-dependent chick intestinal calcium-binding protein. Implications regarding calcium-binding protein function. J Biol Chem 262:6539-45
Wilson, H D; Schedl, H P (1987) Resection of rat small intestine: calcium, phosphorus, and fat balances and 1,25-dihydroxycholecalciferol. Am J Clin Nutr 45:437-42
Gill, H S; Londowski, J M; Corradino, R et al. (1987) Synthesis, biologic activity, and protein binding characteristics of a new vitamin D analog, 22-hydroxyvitamin D3. J Steroid Biochem 28:147-53
Tsai, K S; Wahner, H W; Offord, K P et al. (1987) Effect of aging on vitamin D stores and bone density in women. Calcif Tissue Int 40:241-3
Eastell, R; Riggs, B L; Kumar, R (1987) A primed-infusion technique for rapid estimation of the metabolic clearance rate of 1,25(OH)2D3. Am J Physiol 253:E246-50
Litwiller, R; Fass, D; Kumar, R (1986) The amino acid sequence of the NH2-terminal portion of rat and human vitamin D binding protein: evidence for a high degree of homology between rat and human vitamin D binding protein. Life Sci 38:2179-84
Gill, H S; Londowski, J M; Corradino, R A et al. (1986) The synthesis and biological activity of 22-fluorovitamin D3: a new vitamin D analog. Steroids 48:93-108
Audran, M; Gross, M; Kumar, R (1986) The physiology of the vitamin D endocrine system. Semin Nephrol 6:4-20

Showing the most recent 10 out of 17 publications