Abstract

A five-year study will be conducted to accomplish the following objectives: (1) To evaluate the linear growth in children with chronic renal failure under treatment with 1,25-dihydroxyvitamin-D3 in a randomized, double-blind, carefully controlled, clinical trial. (2) To assess the long-term efficacy and safety of 1,25-dihydroxyvitamin-D3 therapy in children with chronic renal failure through meticulous comparison to a control group on conventional therapy, with particular attention to the rate of progression of chronic renal failure to ensure that 1,25-dihydroxyvitamin-D3 treatment does not exacerbate the primary disorder. (3) To provide long-term evaluation and follow-up of children with chronic renal insufficiency by means of nutritional biochemical indices and antropometric measurements that will yield information never before collected but urgently needed to reveal the extra-skeletal effects of 1,25-dihydroxyvitamin-D3 treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM031370-03
Application #
3152255
Study Section
(SRC)
Project Start
1983-06-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Miller, L A; Noe, H N; Stapleton, F B (1989) Uric acid excretion in children with urolithiasis. J Pediatr 115:923-6
Roth, K S; Chan, J C; Ghatak, N R et al. (1988) Acid alpha-neuraminidase deficiency: a nephropathic phenotype? Clin Genet 34:185-94
Fine, R N; Salusky, I B; Ettenger, R B (1987) The therapeutic approach to the infant, child, and adolescent with end-stage renal disease. Pediatr Clin North Am 34:789-801
Fine, R N (1987) Choosing a treatment modality for the infant, child and adolescent with endstage renal disease. Blood Purif 5:4-13
Santos, F; Smith, M J; Chan, J C (1986) Hypercalciuria associated with long-term administration of calcitriol (1,25-dihydroxyvitamin D3). Action of hydrochlorothiazide. Am J Dis Child 140:139-42
Santos, F; Chan, J C (1986) Renal tubular acidosis in children. Diagnosis, treatment and prognosis. Am J Nephrol 6:289-95
Santos, F; Massie, M D; Chan, J C (1986) Risk factors in aluminum toxicity in children with chronic renal failure. Nephron 42:189-95
Chan, J C; Young, R B; Hartenberg, M A et al. (1985) Calcium and phosphate metabolism in children with idiopathic hypoparathyroidism or pseudohypoparathyroidism: effects of 1,25-dihydroxyvitamin D3. J Pediatr 106:421-6
Alon, U; Chan, J C (1985) Hypocalcemia from deficiency of and resistance to parathyroid hormone. Adv Pediatr 32:439-68
Chan, J C; Alon, U; Hirschman, G M (1985) Renal hypophosphatemic rickets. J Pediatr 106:533-44