Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR020792-15
Application #
2078492
Study Section
Physiology Study Section (PHY)
Project Start
1978-01-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Ohio State University
Department
Physiology
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Liu, Bin; Lee, Ryan S; Biesiadecki, Brandon J et al. (2012) Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity. J Biol Chem 287:20027-36
Lee, Ryan S; Tikunova, Svetlana B; Kline, Kristopher P et al. (2010) Effect of Ca2+ binding properties of troponin C on rate of skeletal muscle force redevelopment. Am J Physiol Cell Physiol 299:C1091-9
Norman, Catalina; Rall, Jack A; Tikunova, Svetlana B et al. (2007) Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities. Am J Physiol Heart Circ Physiol 293:H2580-7
Davis, Jonathan P; Norman, Catalina; Kobayashi, Tomoyoshi et al. (2007) Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J 92:3195-206
Swartz, Darl R; Yang, Zhenyun; Sen, Asok et al. (2006) Myofibrillar troponin exists in three states and there is signal transduction along skeletal myofibrillar thin filaments. J Mol Biol 361:420-35
Luo, Ye; Rall, Jack A (2006) Regulation of contraction kinetics in skinned skeletal muscle fibers by calcium and troponin C. Arch Biochem Biophys 456:119-26
Tikunova, Svetlana B; Davis, Jonathan P (2004) Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C. J Biol Chem 279:35341-52
Davis, Jonathan P; Rall, Jack A; Alionte, Catalina et al. (2004) Mutations of hydrophobic residues in the N-terminal domain of troponin C affect calcium binding and exchange with the troponin C-troponin I96-148 complex and muscle force production. J Biol Chem 279:17348-60
Gomes, Aldrin V; Venkatraman, Gayathri; Davis, Jonathan P et al. (2004) Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem 279:49579-87
Davis, Jonathan P; Rall, Jack A; Reiser, Peter J et al. (2002) Engineering competitive magnesium binding into the first EF-hand of skeletal troponin C. J Biol Chem 277:49716-26

Showing the most recent 10 out of 20 publications