This competitive renewal application requests continuation of core support for the Rochester Epidemiology Project (REP), the medical record linkage system for health care providers to residents of Olmsted County, Minnesota. This unique data resource chronicles the medical care delivered to community residents from the early 1900's to the present and has supported population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in this country. The REP has supported the work of a large number of investigators at Mayo Clinic and other academic institutions permitted the efficient conduct of extramurally-supported studies of conditions with substantial societal impact, including 25 R01 and other research grants, 6 program project/center grants and 17 fellowship/training grants. Since first funded 40 years ago, more than 1,500 manuscripts based on the REP have been published in the peer-reviewed literature, including 351 since our last competitive renewal four years ago These extensive data from a geographically-defined population are virtually unparalleled in this country, and it is essential that this important research resource be preserved and continually updated. Each cycle of this grant has presented an opportunity to not only maintain the core record linkage function, but to enhance its utility as well. For our next project cycle, we propose to update the data resources through the continued enumeration of the population of Olmsted County and linking them with medical events (Aim 1); collate information that can be used to augment genetic studies such as the existence of archived biologic specimens, distributions of genetic polymorphisms and birth certificate information (Aim 2) and enhancing data security and improving logistical support for end-users of the REP (Aim 3). This builds on our accomplishments from the previous funding period that include better timeliness of data collection, addition of new sources of information, and development of tools to increase ease of access while providing greater data security. Thus, the efforts planned for this next funding cycle will provide increased data availability for the growing pool of clinical investigators who, in conjunction with multidisciplinary teams of epidemiologists, statisticians and basic scientists, are exploiting the new sciences to address significant questions with a goal of translating findings into improved medical practice and better health for the population as outlined in the NIH Road Map.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR030582-41
Application #
7074834
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Serrate-Sztein, Susana
Project Start
1995-09-07
Project End
2010-06-30
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
41
Fiscal Year
2006
Total Cost
$577,332
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Zhan, Yiqiang; Clements, Mark S; Roberts, Rosebud O et al. (2018) Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies. Neurobiol Aging 69:111-116
Yoshimasu, Kouichi; Barbaresi, William J; Colligan, Robert C et al. (2018) Adults With Persistent ADHD: Gender and Psychiatric Comorbidities-A Population-Based Longitudinal Study. J Atten Disord 22:535-546
DeSimone, Daniel C; El Rafei, Abdelghani; Challener, Douglas W et al. (2017) Effect of the American Heart Association 2007 Guidelines on the Practice of Dental Prophylaxis for the Prevention of Infective Endocarditis in Olmsted County, Minnesota. Mayo Clin Proc :
Ungprasert, Patompong; Crowson, Cynthia S; Matteson, Eric L (2017) Association of Sarcoidosis With Increased Risk of VTE: A Population-Based Study, 1976 to 2013. Chest 151:425-430
Evers, Stefanie; Bryan, Andrew J; Sanders, Thomas L et al. (2017) Corticosteroid Injections for Carpal Tunnel Syndrome: Long-Term Follow-Up in a Population-Based Cohort. Plast Reconstr Surg 140:338-347
Chamberlain, Alanna M; Alonso, Alvaro; Gersh, Bernard J et al. (2017) Multimorbidity and the risk of hospitalization and death in atrial fibrillation: A population-based study. Am Heart J 185:74-84
Lee, Sangil; Hess, Erik P; Lohse, Christine et al. (2017) Trends, characteristics, and incidence of anaphylaxis in 2001-2010: A population-based study. J Allergy Clin Immunol 139:182-188.e2
Pareek, A; Sanders, T L; Wu, I T et al. (2017) Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County. Osteoarthritis Cartilage 25:1663-1671
Ungprasert, Patompong; Crowson, Cynthia S; Matteson, Eric L (2017) Risk of Malignancy Among Patients With Sarcoidosis: A Population-Based Cohort Study. Arthritis Care Res (Hoboken) 69:46-50
Sanders, Thomas L; Kremers, Hilal Maradit; Bryan, Andrew J et al. (2017) Procedural intervention for arthrofibrosis after ACL reconstruction: trends over two decades. Knee Surg Sports Traumatol Arthrosc 25:532-537

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