Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR030988-15
Application #
2078741
Study Section
Physiology Study Section (PHY)
Project Start
1982-05-01
Project End
1997-12-22
Budget Start
1996-05-01
Budget End
1997-12-22
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Physiology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Siththanandan, V B; Tobacman, L S; Van Gorder, N et al. (2009) Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils. Pflugers Arch 458:761-76
Sumandea, Marius P; Vahebi, Susan; Sumandea, C Amelia et al. (2009) Impact of cardiac troponin T N-terminal deletion and phosphorylation on myofilament function. Biochemistry 48:7722-31
Pavlov, Dmitry; Gerson, Jack H; Yu, Tianwei et al. (2003) The regulation of subtilisin-cleaved actin by tropomyosin/troponin. J Biol Chem 278:5517-22
Piroddi, N; Tesi, C; Pellegrino, M A et al. (2003) Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils. J Physiol 552:917-31
Burkart, Eileen M; Sumandea, Marius P; Kobayashi, Tomoyoshi et al. (2003) Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem 278:11265-72
Homsher, E; Nili, M; Chen, I Y et al. (2003) Regulatory proteins alter nucleotide binding to acto-myosin of sliding filaments in motility assays. Biophys J 85:1046-52
Tobacman, Larry S; Nihli, Mahta; Butters, Carol et al. (2002) The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity. J Biol Chem 277:27636-42
Karibe, A; Tobacman, L S; Strand, J et al. (2001) Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis. Circulation 103:65-71
Strand, J; Nili, M; Homsher, E et al. (2001) Modulation of myosin function by isoform-specific properties of Saccharomyces cerevisiae and muscle tropomyosins. J Biol Chem 276:34832-9
Gordon, A M; Regnier, M; Homsher, E (2001) Skeletal and cardiac muscle contractile activation: tropomyosin ""rocks and rolls"". News Physiol Sci 16:49-55

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