The long-term goal of this project is to provide information that can be applied to the prevention and treatment of injury to the anterior cruciate ligament (ACL) of the knee. The annual incidence of acute ACL disruptions is approximately 1 in 3000. Treatment of the ruptured anterior cruciate ligament is often complicated by the difficulty in predicting from passive physical examination of the knee which patients will be functionally impaired by the loss of this ligament and which patients will have minimal symptoms. Is it possible that altered patterns of locomotion dynamically compensate for loss of the ACT? Quantifying the relationship between altered patterns of locomotion and changes in the anterior-posterior displacement (AP) and internal-external rotation (IE) of the knee is a fundamental step towards answering this question. This information is clinically important since the AP and IE components of knee motion influence strains in secondary restraints (to anterior laxity) such as the medial meniscus of altered patterns of locomotion for ACL deficient knees. A newly developed point cluster technique will be used to quantify knee kinematics during locomotion. The first hypothesis will test if altered patterns of locomotion (characterized by the magnitude of the moment generated by net quadriceps/knee flexor muscles) are correlated with AP and IE displacements at the knee. Another consideration in this study is the possibility that individual anatomical variations can influence the effect of altered patterns of locomotion on knee kinematics. Previous work has implicated the extensor mechanism as a possible cause of these adaptations. The second hypothesis will test if the magnitude of the altered pattern of locomotion (defined by the reduction from normal) in the net quadriceps/knee flexor moment) is correlated with knee extensor anatomy. This study will generate fundamental new information on the patient's ability to dynamically control anterior posterior stability of the knee joint in the absence of anterior cruciate ligament. This study will also help to identify critical variables that should be considered in a larger prospective clinical outcome study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR039421-11
Application #
6632522
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Program Officer
Panagis, James S
Project Start
1988-04-01
Project End
2005-05-31
Budget Start
2003-09-15
Budget End
2004-05-31
Support Year
11
Fiscal Year
2003
Total Cost
$373,203
Indirect Cost
Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Erhart-Hledik, Jennifer C; Chu, Constance R; Asay, Jessica L et al. (2018) Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction. J Orthop Res 36:1478-1486
Favre, Julien; Erhart-Hledik, Jennifer C; Blazek, Katerina et al. (2017) Anatomically Standardized Maps Reveal Distinct Patterns of Cartilage Thickness With Increasing Severity of Medial Compartment Knee Osteoarthritis. J Orthop Res 35:2442-2451
Titchenal, Matthew R; Chu, Constance R; Erhart-Hledik, Jennifer C et al. (2017) Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes. Am J Sports Med 45:915-921
Erhart-Hledik, Jennifer C; Chu, Constance R; Asay, Jessica L et al. (2017) Gait mechanics 2 years after anterior cruciate ligament reconstruction are associated with longer-term changes in patient-reported outcomes. J Orthop Res 35:634-640
Favre, Julien; Erhart-Hledik, Jennifer C; Chehab, Eric F et al. (2016) General scheme to reduce the knee adduction moment by modifying a combination of gait variables. J Orthop Res 34:1547-56
Zabala, Michael E; Favre, Julien; Andriacchi, Thomas P (2015) Relationship Between Knee Mechanics and Time Since Injury in ACL-Deficient Knees Without Signs of Osteoarthritis. Am J Sports Med 43:1189-96
Andriacchi, Thomas P; Favre, Julien; Erhart-Hledik, J C et al. (2015) A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease. Ann Biomed Eng 43:376-87
Bevill, S L; Boyer, K A; Andriacchi, T P (2014) The regional sensitivity of chondrocyte gene expression to coactive mechanical load and exogenous TNF-? stimuli. J Biomech Eng 136:091005
Favre, J; Erhart-Hledik, J C; Andriacchi, T P (2014) Age-related differences in sagittal-plane knee function at heel-strike of walking are increased in osteoarthritic patients. Osteoarthritis Cartilage 22:464-71
Scanlan, Sean F; Donahue, Joseph P; Andriacchi, Thomas P (2014) The in vivo relationship between anterior neutral tibial position and loss of knee extension after transtibial ACL reconstruction. Knee 21:74-9

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