Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
7R01AR040574-07
Application #
2006206
Study Section
Special Emphasis Panel (ZRG4-GMA-2 (01))
Project Start
1990-07-01
Project End
2000-11-30
Budget Start
1996-09-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Dermatology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Rys-Sikora, Krystyna E; Pentland, Alice P; Konger, Raymond L (2003) Pertussis toxin-sensitive secretory phospholipase A2 expression and motility in activated primary human keratinocytes. J Invest Dermatol 120:86-95
Konger, Raymond L; Scott, Glynis A; Landt, Yvonne et al. (2002) Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression. Am J Pathol 161:2065-78
Rys-Sikora, K E; Konger, R L; Schoggins, J W et al. (2000) Coordinate expression of secretory phospholipase A(2) and cyclooxygenase-2 in activated human keratinocytes. Am J Physiol Cell Physiol 278:C822-33
Pentland, A P; Schoggins, J W; Scott, G A et al. (1999) Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis 20:1939-44
Chen, X; Gresham, A; Morrison, A et al. (1996) Oxidative stress mediates synthesis of cytosolic phospholipase A2 after UVB injury. Biochim Biophys Acta 1299:23-33
Gresham, A; Masferrer, J; Chen, X et al. (1996) Increased synthesis of high-molecular-weight cPLA2 mediates early UV-induced PGE2 in human skin. Am J Physiol 270:C1037-50
Malaviya, R; Morrison, A R; Pentland, A P (1996) Histamine in human epidermal cells is induced by ultraviolet light injury. J Invest Dermatol 106:785-9
Miller, C C; Hale, P; Pentland, A P (1994) Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. J Biol Chem 269:3529-33
Okada, N; Pentland, A P; Falk, P et al. (1994) M protein and protein F act as important determinants of cell-specific tropism of Streptococcus pyogenes in skin tissue. J Clin Invest 94:965-77
Kang-Rotondo, C H; Miller, C C; Morrison, A R et al. (1993) Enhanced keratinocyte prostaglandin synthesis after UV injury is due to increased phospholipase activity. Am J Physiol 264:C396-401

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