Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR040593-07
Application #
2080146
Study Section
Special Emphasis Panel (ZRG2-PHY (02))
Project Start
1990-06-30
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Physiology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Khairy, Khaled; Foo, Jijinn; Howard, Jonathon (2010) Shapes of Red Blood Cells: Comparison of 3D Confocal Images with the Bilayer-Couple Model. Cell Mol Bioeng 1:173-181
Brouhard, Gary J; Stear, Jeffrey H; Noetzel, Tim L et al. (2008) XMAP215 is a processive microtubule polymerase. Cell 132:79-88
Pecreaux, Jacques; Roper, Jens-Christian; Kruse, Karsten et al. (2006) Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Curr Biol 16:2111-22
Howard, J (2006) Elastic and damping forces generated by confined arrays of dynamic microtubules. Phys Biol 3:54-66
Schief, William R; Clark, Rutilio H; Crevenna, Alvaro H et al. (2004) Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism. Proc Natl Acad Sci U S A 101:1183-8
Ohi, Ryoma; Sapra, Tanuj; Howard, Jonathan et al. (2004) Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell 15:2895-906
Hunter, Andrew W; Caplow, Michael; Coy, David L et al. (2003) The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends. Mol Cell 11:445-57
Coy, D L; Wagenbach, M; Howard, J (1999) Kinesin takes one 8-nm step for each ATP that it hydrolyzes. J Biol Chem 274:3667-71
Coy, D L; Hancock, W O; Wagenbach, M et al. (1999) Kinesin's tail domain is an inhibitory regulator of the motor domain. Nat Cell Biol 1:288-92
Hancock, W O; Howard, J (1999) Kinesin's processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domains. Proc Natl Acad Sci U S A 96:13147-52

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