Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR043380-01A1
Application #
2083085
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1996-02-20
Project End
2001-01-31
Budget Start
1996-02-20
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Pathology
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Maruthappu, T; Posafalvi, A; Castelletti, S et al. (2018) Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. Br J Dermatol :
Rübsam, Matthias; Broussard, Joshua A; Wickström, Sara A et al. (2018) Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective. Cold Spring Harb Perspect Biol 10:
Yang, Ruiguo; Broussard, Joshua A; Green, Kathleen J et al. (2018) Techniques to stimulate and interrogate cell-cell adhesion mechanics. Extreme Mech Lett 20:125-139
Broussard, Joshua A; Yang, Ruiguo; Huang, Changjin et al. (2017) The desmoplakin-intermediate filament linkage regulates cell mechanics. Mol Biol Cell 28:3156-3164
Najor, Nicole Ann; Fitz, Gillian Nicole; Koetsier, Jennifer Leigh et al. (2017) Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex. Elife 6:
Dubash, Adi D; Kam, Chen Y; Aguado, Brian A et al. (2016) Plakophilin-2 loss promotes TGF-?1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J Cell Biol 212:425-38
Broussard, Joshua A; Getsios, Spiro; Green, Kathleen J (2015) Desmosome regulation and signaling in disease. Cell Tissue Res 360:501-12
Albrecht, Lauren V; Zhang, Lichao; Shabanowitz, Jeffrey et al. (2015) GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics. J Cell Biol 208:597-612
Todorovic, Viktor; Koetsier, Jennifer L; Godsel, Lisa M et al. (2014) Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation. Mol Biol Cell 25:3749-64
Patel, Dipal M; Dubash, Adi D; Kreitzer, Geri et al. (2014) Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions. J Cell Biol 206:779-97

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