Molecular Genetics of Lyme Arthritis Susceptibility

Weis, Janis J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 5R01AR043521-03
• Application #: 2083227
• Study Section: Special Emphasis Panel (SRC (75))
• Project Start: 1994-09-30
• Project End: 1999-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Utah
• Department: Pathology
• Type: Schools of Medicine
• City: Salt Lake City
• State: UT
• Country: United States
• Zip Code: 84112

Publications

Whiteside, Sarah K; Snook, Jeremy P; Williams, Matthew A et al. (2018) Bystander T Cells: A Balancing Act of Friends and Foes. Trends Immunol 39:1021-1035

Whiteside, Sarah K; Snook, Jeremy P; Ma, Ying et al. (2018) IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis. J Immunol 200:1457-1470

Paquette, Jackie K; Ma, Ying; Fisher, Colleen et al. (2017) Genetic Control of Lyme Arthritis by Borrelia burgdorferi Arthritis-Associated Locus 1 Is Dependent on Localized Differential Production of IFN-? and Requires Upregulation of Myostatin. J Immunol 199:3525-3534

Pioli, Peter D; Whiteside, Sarah K; Weis, Janis J et al. (2016) Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs. Immunobiology 221:618-33

Lochhead, Robert B; Zachary, James F; Dalla Rosa, Luciana et al. (2015) Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. PLoS One 10:e0135142

Pioli, Peter D; Chen, Xinjian; Weis, Janis J et al. (2015) Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3. Cell Immunol 295:1-18

Bramwell, Kenneth K C; Mock, Kelton; Ma, Ying et al. (2015) ?-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli. J Immunol 195:1647-56

Ma, Ying; Bramwell, Kenneth K C; Lochhead, Robert B et al. (2014) Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production. J Immunol 193:6050-60

Bramwell, Kenneth K C; Teuscher, Cory; Weis, Janis J (2014) Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity. Front Cell Infect Microbiol 4:76

Lochhead, Robert B; Ma, Ying; Zachary, James F et al. (2014) MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog 10:e1004212