Core - Biochemistry

Abstract

Core B: Biochemistry The Biochemistry Core provides specimen processing and chemical determinations on serum, urine, stool, and dietary specimens. It also is responsible for acquiring stool, urine, and blood specimens for mailing to outside reference laboratories. Assays routinely carried out include calcium, phosphorus, protein, creatinine, hydroxyproline, FSH, 25- hydroxyvitamin D, 1,25 dihydroxyvitamin D, bone Gla protein, estradiol, as well as radiochemical determinations of 45Ca and 47Ca. As a general biochemistry laboratory, this core laboratory is equipped to provide a number of other chemical determinations, such as fecal fat, serum strontium, and certain other tests, including urine sodium and potassium.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 5R01AR045349-01
• Application #: 2661783
• Budget Start: 1996-10-01
• Budget End: 1997-09-30
• Support Year: 1
• Fiscal Year: 1997

Institution

• Name: Creighton University
• City: Omaha
• State: NE
• Country: United States
• Zip Code: 68178

Publications

Recker, R R; Kimmel, D B; Dempster, D et al. (2011) Issues in modern bone histomorphometry. Bone 49:955-64

Chen, Xiang-Ding; Xiao, Peng; Lei, Shu-Feng et al. (2010) Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians. J Bone Miner Res 25:339-55

Liu, Pengyuan; Lu, Yan; Recker, Robert R et al. (2010) Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women. Menopause 17:185-90

Lu, Yan; Liu, Pengyuan; Recker, Robert R et al. (2010) TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. Menopause 17:1048-54

Liu, Pengyuan; Lu, Yan; Recker, Robert R et al. (2010) ALOX12 gene is associated with the onset of natural menopause in white women. Menopause 17:152-6

Chen, Yuan; Shen, Hui; Yang, Fang et al. (2009) Choice of study phenotype in osteoporosis genetic research. J Bone Miner Metab 27:121-6

Lei, Shufeng; Deng, Feiyan; Xiao, Peng et al. (2009) Bivariate whole-genome linkage scan for bone geometry and total body fat mass. J Genet Genomics 36:89-97

Zhang, Zhi-Xin; Lei, Shu-Feng; Deng, Fei-Yan et al. (2009) Bivariate genome-wide linkage analysis for traits BMD and AAM: effect of menopause on linkage signals. Maturitas 62:16-20

He, Li-Na; Recker, Robert R; Deng, Hong-Wen et al. (2009) A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. Maturitas 62:37-41

Yan, H; Liu, Y-J; Zhou, Q et al. (2009) Comparison of whole genome linkage scans in premenopausal and postmenopausal women: no bone-loss-specific QTLs were implicated. Osteoporos Int 20:771-7