Abstract

This program in biomathematics and computing at the University of Texas M.D. Anderson Hospital and Tumor Institute supports the needs for design and analysis of experiments, data base management and modelling in this comprehensive cancer center. This is accomplished through: 1) Basic research in biomathematics, biostatistics, and biomedical computation, 2) consultation and collaborative support for the staff of the institution, 3) provision of programs and computational facilities for the center. Core projects in the basic research activity of the staff include: 1) Computation for Radiation Dosimetry, 2) Computational Methods for Dose Modifying Factors, 3) Cell Kinetics, 4) Planning and Analysis of Clinical Studies, 5) Survival Time Studies, 6) DNA-Distribution Analysis and Data Management, 7) Early Termination Tules for Phase II Clinical Trials, 8) Theory of Thermal Denaturation of DNA, 9) Software Developments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA011430-21
Application #
3163472
Study Section
(SSS)
Project Start
1978-07-01
Project End
1987-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
21
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

White, R A; Pollack, A; Terry, N H et al. (1994) Double labelling to obtain S phase subpopulations: application to determine cell kinetics of diploid cells in an aneuploid tumour. Cell Prolif 27:123-37
White, R A; Pollack, A; Terry, N H (1994) Simultaneous cytokinetic measurement of aneuploid tumors and associated diploid cells following continuous labelling with chlorodeoxyuridine. Cytometry 15:311-9
Pollack, A; Terry, N H; White, R A et al. (1994) Proliferation kinetics of recruited cells in a mouse mammary carcinoma. Cancer Res 54:811-7
Obeyesekere, M N; Tucker, S L; Zimmerman, S O (1994) A model for regulation of the cell cycle incorporating cyclin A, cyclin B and their complexes. Cell Prolif 27:105-13
Jiang, G L; Tucker, S L; Guttenberger, R et al. (1994) Radiation-induced injury to the visual pathway. Radiother Oncol 30:17-25
Johnston, D A; Tang, K S; Zimmerman, S (1993) Band features as classification measures for G-banded chromosome analysis. Comput Biol Med 23:115-29
Auger, M; Katz, R L; Johnston, D A et al. (1993) Quantitation of immunocytochemical estrogen and progesterone receptor content in fine needle aspirates of breast carcinoma using the SAMBA 4000 image analysis system. Anal Quant Cytol Histol 15:274-80
Pollack, A; White, R A; Cao, S et al. (1993) Calculating potential doubling time using monoclonal antibodies specific for two halogenated thymidine analogues. Int J Radiat Oncol Biol Phys 27:1131-9
White, R A; Terry, N H (1992) A quantitative method for evaluating bivariate flow cytometric data obtained using monoclonal antibodies to bromodeoxyuridine. Cytometry 13:490-5
Tucker, S L; Travis, E L (1992) Time course for the hazard of radiation-induced pneumonitis death in mice. Int J Radiat Biol 62:627-39

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