Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA011778-15S2
Application #
3163553
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1979-05-01
Project End
1985-08-31
Budget Start
1984-05-01
Budget End
1985-08-31
Support Year
15
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Zhao, Haiyan; Bray, Tom; Ouellette, Marc et al. (2003) Structure of pteridine reductase (PTR1) from Leishmania tarentolae. Acta Crystallogr D Biol Crystallogr 59:1539-44
Chang, C F; Bray, T; Varughese, K I et al. (1999) Comparative properties of three pteridine reductases. Adv Exp Med Biol 463:403-10
Chang, C F; Bray, T; Whiteley, J M (1999) Mutant PTR1 proteins from Leishmania tarentolae: comparative kinetic properties and active-site labeling. Arch Biochem Biophys 368:161-71
Kiefer, P M; Grimshaw, C E; Whiteley, J M (1997) The comparative interaction of quinonoid (6R)-dihydrobiopterin and an alternative dihydropterin substrate with wild-type and mutant rat dihydropteridine reductases. Biochemistry 36:9438-45
Wang, J; Leblanc, E; Chang, C F et al. (1997) Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1. Arch Biochem Biophys 342:197-202
Kiefer, P M; Varughese, K I; Su, Y et al. (1996) Altered structural and mechanistic properties of mutant dihydropteridine reductases. J Biol Chem 271:3437-44
Varughese, K I; Xuong, N H; Kiefer, P M et al. (1994) Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases. Proc Natl Acad Sci U S A 91:5582-6
Varughese, K I; Xuong, N H; Whiteley, J M (1994) Structural and mechanistic implications of incorporating naturally occurring aberrant mutations of human dihydropteridine reductase into a rat model. Int J Pept Protein Res 44:278-87
Whiteley, J M; Xuong, N H; Varughese, K I (1993) Is dihydropteridine reductase an anomalous dihydrofolate reductase, a flavin-like enzyme, or a short-chain dehydrogenase? Adv Exp Med Biol 338:115-21
Varughese, K I; Su, Y; Skinner, M M et al. (1993) Two crystal structures of rat liver dihydropteridine reductase. Adv Exp Med Biol 338:123-6

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