Abstract

Our goal is to study the mechanisms of immune defense against tumors. Over the past year we have carried out the following projects: (1) studies on the biochemical mechanisms of macrophage activation; (2) purification and characterization of a cytotoxic factor from activated macrophages and studies on the mechanisms of action of this factor; (3) studies on the mechanisms of chemoattractant action of lysophosphatidylcholine on lymphocytes; and (4) characterization of monoclonal antibodies against human leukemia-associated antigens. (MB)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA014113-13
Application #
3163873
Study Section
Immunobiology Study Section (IMB)
Project Start
1978-08-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Noble, P W; McKee, C M; Cowman, M et al. (1996) Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J Exp Med 183:2373-8
Lokuta, M A; Maher, J; Noe, K H et al. (1996) Mechanisms of murine RANTES chemokine gene induction by Newcastle disease virus. J Biol Chem 271:13731-8
Shin, H S; Drysdale, B E; Shin, M L et al. (1994) Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2. Mol Cell Biol 14:2914-25
Symer, D E; Paznekas, W A; Shin, H S (1993) A requirement for membrane-associated phospholipase A2 in platelet cytotoxicity activated by receptors for immunoglobulin G and complement. J Exp Med 177:937-47
Nishijima, J; Wright, T M; Hoffman, R D et al. (1989) Lysophosphatidylcholine metabolism to 1,2-diacylglycerol in lymphoblasts: involvement of a phosphatidylcholine-hydrolyzing phospholipase C. Biochemistry 28:2902-9
Wagner, J E; Johnson, R J; Santos, G W et al. (1989) Systemic monoclonal antibody therapy for eliminating minimal residual leukemia in a rat bone marrow transplant model. Blood 73:614-8
Wright, T M; Hoffman, R D; Nishijima, J et al. (1988) Leukocyte chemoattraction by 1,2-diacylglycerol. Proc Natl Acad Sci U S A 85:1869-73
Drysdale, B E; Agarwal, S; Shin, H S (1988) Macrophage-mediated tumoricidal activity: mechanisms of activation and cytotoxicity. Prog Allergy 40:111-61
Agarwal, S; Drysdale, B E; Shin, H S (1988) Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation. J Immunol 140:4187-92
Drysdale, B E; Yapundich, R A; Shin, M L et al. (1987) Lipopolysaccharide-mediated macrophage activation: the role of calcium in the generation of tumoricidal activity. J Immunol 138:951-6

Showing the most recent 10 out of 14 publications