Abstract

The aim of this project is to identify and analyze in detail the cell-surface binding sites (""""""""receptors"""""""") for fibronectin and other extracellular matrix molecules. These receptors will be studied in fibroblasts and platelets. Biochemical, cell biological and molecular biological techniques, including cloning of cDNAs for the receptor proteins, will be used to elucidate the structure and function of these receptors and determine whether they constitute transmembrane connections between the extracellular matrix and the cytoskeleton. Potential changes during oncogenic transformation, platelet activation and embryological development will be analyzed. The role of extracellular matrix in the control of cell migration will be investigated. This work should provide information relevant to the understanding of cell adhesion and migration and the role which these processes play in malignancy, hemostasis, thrombosis and embryological development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA017007-11
Application #
3164586
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1977-05-01
Project End
1990-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Roper, Jatin; Tammela, Tuomas; Cetinbas, Naniye Malli et al. (2017) In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol 35:569-576
Xie, Liang; Duncan, Michael B; Pahler, Jessica et al. (2011) Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A 108:9939-44
Hynes, Richard O (2009) The extracellular matrix: not just pretty fibrils. Science 326:1216-9
Xu, Lei; Shen, Steven S; Hoshida, Yujin et al. (2008) Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res 6:760-9
McCarty, Joseph H; Barry, Marc; Crowley, Denise et al. (2008) Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol 172:1740-7
Wong, Sunny Y; Crowley, Denise; Bronson, Roderick T et al. (2008) Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis 25:109-18
Wong, Sunny Y; Haack, Herbert; Kissil, Joseph L et al. (2007) Protein 4.1B suppresses prostate cancer progression and metastasis. Proc Natl Acad Sci U S A 104:12784-9
Xu, Lei; Hynes, Richard O (2007) GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle 6:160-5
Wong, Sunny Y; Hynes, Richard O (2007) Tumor-lymphatic interactions in an activated stromal microenvironment. J Cell Biochem 101:840-50
Wong, Sunny Y; Hynes, Richard O (2006) Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle 5:812-7

Showing the most recent 10 out of 68 publications